Progesterone Research Network        

Your Information Source on Bio-Identical Natural Progesterone

Questions? Call (877) 880-0170                                                                                                                         

Articles on Menstruation

PMS (Premenstrual Syndrome)
Based on the research of John R. Lee, M.D.

What is PMS?

PMS is a disorder characterized by a set of hormonal changes that trigger disruptive symptoms for up to two weeks prior to menstruation. Often symptoms tend to taper off with menstruation and women remain symptom-free until the two weeks or so prior to the next menstrual period. Then the symptoms begin again.


Many symptoms have been attributed to PMS. After complaints of feeling “out-of-control”, anxious, depressed and having uncontrollable crying spells, the most common complaints are headache and fatigue. But symptoms may vary from month to month and there may even be symptom-free months. Symptoms may be both physical and emotional. Symptoms usually occur 2 weeks prior to onset of the menstrual cycle.

Physical Symptoms

- Headache - Migraine - Depression
- Fatigue
- Constipation
- Backache
- Abdominal cramping
- Fluid retention
- Weight gain
- Heart palpitations

Emotional & Behavioral Symptoms

- Anxiety
- Irritability
- Tension
- Lack of coordination
- Lowered libido
- Decreased work or social performance
- Panic attacks
- Feelings of being “out of control”

Possible Causes

PMS seems to be related to fluctuations in estrogen and progesterone levels in the body. The following are considered as causes of PMS:

• Estrogen-progesterone imbalance (Estrogen dominance)
• Stress and higher levels of cortisol (cortisol competes with progesterone for common  
• Carbohydrate metabolism changes
• Retention of sodium and water by the kidneys
• hypoglycemia (low blood sugar)


The following recommendations can help reduce the occurrence of PMS symptoms.

• Correct estrogen dominance with Natural Progesterone Crème
• Regular exercise (3 to 5 times each week)
• Eat a plant – based, fiber-rich diet of fresh, organic vegetables and fruits, nuts, seeds,
  whole grains and legumes.
• Get Adequate sleep and rest
• Take a daily multivitamin/mineral that includes zing (10 mg), B complex (all of the B
   vitamins), vitamin C (500-1000 mg), magnesium (300-400 mg) and Vitamin E (400 IU). In
   addition take vitamin B6 (50 mg).
• Take Borage Oil or Evening Primrose Oil to treat symptoms (400 mg GLA oils once or
   twice daily)

Don’t give up! According to Dr. Lee, it may take up to 3 months of consistent use of progesterone crème to see results, although many women report feeling better in a very short time. Then continue using your natural progesterone to keep your hormones balanced.