Progesterone Research Network        

Your Information Source on Bio-Identical Natural Progesterone

Questions? Call (877) 880-0170                                                                                                                         

Articles on Osteoporosis

Based on Research by Dr. John R. Lee

Dr. According to John R. Lee, M.D., founder of the Progesterone Research Institute, natural progesterone may help to build new bone by stimulating osteoblastic activity.

Dr. Lee taught that the lack of progesterone caused a decrease in new bone formation and thus bone resorption occurs in the osteoclast; bone building occurs in the osteoblasts which are stimulated by progesterone.

What estrogen does is hold OLD bone in place; not build NEW bone. Eventually old bone just gets older and eventually will become weak and fragile. New bone is strong and resists fracture.

According to the Health & Science Research Institute, U.S.A, Women using transdermal progesterone experience and average of 7-8% bone mass density increase the first year of progesterone use, 4-5% the second year and 3-4% the third year.

Another study was conducted with 100 patients ranging from ages 38-83. They were all menopausal or post menopausal. Each patient was followed a minimum of 3 years. In the 63 women given natural progesterone, the benefit proved to be extraordinary showing that in 3 years, instead of losing 4.5% of bone as expected, the subjects acturally increased thier bone density by an average of 15.4%, the greatest increase occurring in the 1st year. The most interesting news was that the older the woman, the better results! So, it is never too late. 

According to studies by John R. Lee, M.D., who used natural progesterone in his practive to treat and prevent osteoporosis:

  • Estrogen alone can retard but NOT reverse osteoporosis
  • Fosomax, a bisphosphonate drug inhibits bone resorption, but eventually the user ends up with a skeleton of old bone which is more crystallized and more likely to fracture.
  • Estrogen can not progect against osteoporosis when progesterone is absent
  • The addition of natural progesterone should be beneficial in preventing or treating premenopausal osteoporosis
  • Since some estrogen is produced endogenously (within the body) in postmenopausal women, it is possible that supplementation with progesterone alone is sufficient to prevent and/or reverse osteoporosis
  • Since 1982, Dr. Lee treated postmenopausal osteoporosis with transdermal natural progesterone creme along with a program of diet, mineral and vitamin supplements, and exercise, and demonstrated true reversal of osteoporosis even in patients who did not use estrogen supplements