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Articles on Natural Progesterone Cream

Conditions & Instructions for Natural Progesterone

Based on the research & writings of John R. Lee, M.D. who used natural progesterone in his medical practice.
Dr. Lee used natural progesterone for these conditions as described below.

For further information regarding each condition, you may consult Dr. Lee’s books,
What Your Doctor May Not Tell You About Menopause
What Your Doctor May Not Tell You About Premenopause

Heavy Bleeding can occur when the uterus is exposed to high levels of estrogen that stimulate excessive growth of the uterine lining. Dr. Lee found that heavy bleeding could be relieved by balancing the body with progesterone. He had women use relatively high doses of progesterone for a month or so.


Dr. Lee’s directions: Use at least ½ tsp twice daily from day 10-26 of your cycle. When bleeding subsides, revert to ¼ tsp. twice daily

Fibrocystic Breasts are fluid-filled fibrous cysts, usually tender and painful. According to Dr. Lee, they can be a sign of estrogen dominance. (progesterone deficiency) Women in his practice responded very well to progesterone cream use, often reverting to normal breast tissue.


Dr. Lee’s directions: Use at least 1/4 tsp twice daily from day 12-26 of your cycle. It can be rubbed directly on the breasts for faster relief. Once the cysts have cleared up reduce the dose to find the smallest dose that is effective each month and continue treatment through menopause.

Fibroid Tumors are benign (non-cancerous) tumors found on the woman’s uterus most commonly in women in the 30’s or 40’s. Women with fibroid tumors are often estrogen dominant and have low levels of progesterone. With the exception of cancer or severe uterine bleeding, Dr. Lee used natural progesterone to treat uterine fibroids. He stated that if progesterone is used to contain the size of the fibroid until menopause, the reduced estrogen production in menopause and beyond usually causes the fibroids to atrophy. Ultrasound tests can be obtained to check results. Dr. Lee felt a good result would show the fibroid size had not increased. He often saw a decrease in size by 10-15% with ultrasound testing.


Dr. Lee’s directions: Use at least 1/4 tsp twice daily from day 10 to day 26-30 of your cycle (whenever your cycle usually ends)

Ovarian Cysts are fluid-filled sacs on the uterus that does not dissolve or break during the menstrual cycle to release a mature egg (ovulation). These cysts can be stimulated by estrogen dominance to grow even larger with each menstrual cycle, often causing pain and discomfort or bleeding. When progesterone levels are normalized for a few months, the cysts are usually just reabsorbed by the body.


Dr. Lee’s directions: Use natural progesterone on days 5-26 for 3 cycles to temporarily suppress ovulation. According to Dr. Lee, ovulation often occurs on the fourth cycle.

Endometriosis is a condition in which fragments of endometrial tissue are present in areas where they don’t belong. Endometrial fragments building up within the uterus, increase in size, swell with blood, and bleed into the surrounding tissue at menstruation. Dr. Lee used high doses of progesterone cream to reduce the pain of endometriosis, often seeing improvement by the 3rd or 4th month, although it sometimes took up to 6 months. It requires patience as the inflammatory sites begin to heal. Dr. Lee recommended progesterone use for women who did not want to take drugs that have undesirable side effects or did not wish to have surgery or who had a surgery which had failed.


Dr. Lee’s directions: Use at least 1/2 tsp twice daily from day 8-26 of your cycle. This reduces the effects of the estrogen which stimulates the growth of the endometrial tissue. Once the pain begins to subside, decrease the dose and use from day 12-26. Increase if the pain begins to flare up.

Loss of Libido is often a symptom of estrogen dominance. The hormones that improve libido are progesterone and testosterone. Testosterone supplementation can have masculinizing effects and cause facial hair growth and acne, so progesterone is a more viable choice.


Dr. Lee’s directions:  
(Menopausal Women)  Use 1/4 tsp twice daily for 25 days per month
(Menstruating Woman)  Use 1/4 tsp twice daily on days 12-26 of the cycle

Cramping can occur as the result of an estrogen dominant uterus and sometimes can be a symptom of endometriosis.


Dr. Lee’s directions: Use at least 1/4 tsp twice daily from day 12-26 of your cycle. Some women report that rubbing the progesterone on the abdomen during severe episodes has shown relief. Allow up to 6 months of use to see optimum results.

Facial Hair may be due to a hormonal imbalance and other symptoms of estrogen dominance.


Dr. Lee’s directions: Use at least 1/4 of tsp twice daily. You can rub it directly to the site of excess facial hair. If you are still menstruating, use it from day 12-26 of your cycle, otherwise use it for 25 days of the month. Allow 6 months of use.

Osteoporosis is a disease of bone loss. In one study, natural progesterone was given to 100 women with osteoporosis. The women ranged in age from 38 to 83 and most had already lost height from the disease. After 6 months of natural progesterone use, all of the women had stopped losing bone and had actually gained new bone. Bone density increased up to 10% in the women. After 6 months, their bone density continued to increase by 3-5% more per year. Within 3 years, many of the women had achieved healthy bone density levels. Neither the woman’s age or the severity of her bone loss affected the study. As a mater of fact, those women who had the worse bone loss at the beginning of the study had the fastest increase in bone density when using natural progesterone.


Dr. Lee’s directions:  
Use 1/4 tsp twice daily day 12-26 for menstruating women
Use 1/4 tsp twice daily for 25 days of the month for menopausal women

Men - Enlarged Prostate is a condition known as condition benign prostatic hyperplasia or benign prostatic hypertrophy (BPH). The prostate gland enlarges pressing against the urethra causing the bladder to contract more frequently, therefore causing frequent urination. It is believed that excess estrogens may be causing testosterone to convert to DHT which is harmful to the prostate. Balancing with natural progesterone may counteract these excess estrogens.

  Dr Lee’s directions: Use at least 8-10 mg once daily.